Six-item cognitive impairment test (6CIT): pragmatic diagnostic accuracy study for dementia and MCI | Semantic Scholar (2024)

Evidence is presented that the 6-CIT has excellent dementia screening performance and could be used as a potential alternative to the MMSE, and may provide an opportunity for early detection of dementia.

The shorter administration time of the 6CIT, suggests it may be useful when assessing or monitoring cognitive impairment in busy memory clinics, though larger samples are required to evaluate.

The 6CIT is a brief, validated screening tool that may be preferable to the Mini-Mental State Examination (MMSE) due to its brevity and ease of use and there are data to suggest that it is now used more frequently than the MMSE in primary care settings.

The Six-Item Cognitive Impairment Test (6-CIT) is a feasible instrument for cognitive screening among older adults attending a general practitioner or hospital, and its validity in primary care use has been questioned and there are limited validation studies on its use in secondary care.

The Six-itemCognitive Impairment Test (6CIT) was administered to consecutive new outpatients attending a dedicated cognitive disorders clinic over a 12-month period and experience in this clinic indicates that 6CIT 7/8 threshold is now being used in some primary care settings as criterion for onward referral of patients for further assessment.

It is demonstrated that 6-CIT is a reliable cognitive screening tool in ED, offering excellent sensitivity and specificity with a 8/9 points cut-off score.

The proposed 6CIT-P threshold for cognitive impairment is ≥10 in the Portuguese population, which gives sensitivity of 82.78% and specificity of 84.84%.

The SKT detected cognitive decline at early stages but produced increased rates of false positives, and the correlation between SKT and MMSE scores reached r = –0.67.

Data from several pragmatic diagnostic test accuracy studies examining various cognitive screening instruments in a secondary care setting were analysed to correlate measures of test diagnostic accuracy and test duration, building on the findings of a preliminary study.

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The 6-CIT is a brief and simple test of cognition, which correlates reasonably well with the MMSE in a naturalistic setting and performs well as a screening instrument for dementia, which makes it a more appropriate test for primary care usage.

The 6CIT's psychometric properties in a real-world setting suggest that the test is not suited as a routine screening instrument and highlights the need for training GPs in the conduct of cognitive screening before such procedures can be implemented on a routine basis.

If 6CIT is to facilitate the aims of the Dementia Commissioning for Quality and Innovation in closing the dementia diagnosis gap, more widespread use will be required, with implications for training in its use.

Evidence to date suggests for those wishing to use brief battery tests then the original MMSE or the AMTS should be considered in primary care and either the 6-CIT or the MINI-COG should be considering in specialist settings.

The 6-CIT is a brief, validated screening tool that may be preferable to the currently, and more widely, used Mini-Mental State Examination (MMSE).

The routine incorporation of effect size calculations into diagnostic accuracy studies merits consideration in order to facilitate the comparison of the relative value of CSI.

Routine incorporation of weighted comparison or other similar net benefit measures into diagnostic accuracy studies merits consideration to better inform clinicians of the relative value of cognitive screening instruments.

Cognitive assessment is commonly used for the following reasons: screening for cognitive impairment; differential diagnosis of cause; and rating of severity of disorder, or monitoring disease progression, which form the basis of the structure of this review.

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